Peripheral neuralgia of the hand occurs due to damage to the peripheral nerves, often resulting from trauma, diabetes, infections, or a vitamin B12 deficiency. This condition leads to symptoms such as pain, weakness, tingling, numbness, and sometimes even loss of sensation. In some cases, it may cause autonomic changes like fluctuations in heart rate and blood pressure. Proper management of peripheral neuralgia requires a comprehensive, multimodal approach, including pain relievers, anti-neuropathic medications, nerve blocks, physiotherapy, and rehabilitation.